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目的分析揭阳市b型流感嗜血杆菌结合疫苗预防接种不良反应数据,评价其接种后的安全性,为在全市推广应用,制订免疫程序提供科学依据。方法汇总揭阳市60多家预防接种门诊上报的1.5万针次的Hib结合疫苗儿童预防接种后发生的不良反应现场观察和主动性回访监测数据,采用描述性流行病学分析方法。结果接种后总的不良反应发生率较低,为3.0%;且表现轻微,均可在72 h内恢复;其中弱、中、强反应率分别为1.4%、1.2%、0.5%,各组反应率比较差异无统计学意义(P>0.05);局部反应率为2.1%;24~48 h两个回访时间段发生发热反应的人群差异无统计学意义(P>0.05)。结论 Hib结合疫苗安全性较高,接种后未监测到严重的不良反应发生,加强接种后的不良反应监测,及时处置发生的异常反应。
Objective To analyze the data of prevention and treatment adverse reactions of Haemophilus influenzae type b conjugate vaccine in Jieyang City and evaluate the safety after inoculation in order to provide a scientific basis for popularizing and applying immunization program in the whole city. Methods A total of 15 cases of Hib conjugate vaccine reported by more than 60 vaccination clinics in Jieyang city were collected from on-site observation and active follow-up surveillance of adverse reactions after vaccination. Descriptive epidemiological analysis methods were used. Results The incidence of adverse reactions after inoculation was low at 3.0%. The mild and moderate reactions were recovered within 72 hours. The rates of weak, moderate and strong reactions were 1.4%, 1.2% and 0.5% (P> 0.05). The local response rate was 2.1%. There was no significant difference between the two groups in the response time of 24-48 h (P> 0.05). Conclusions The Hib conjugate vaccine is safe, no serious adverse reactions are detected after inoculation, the monitoring of adverse reactions after vaccination is strengthened, and the abnormal reaction occurs promptly.