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目的检测乙肝表面抗原阳性孕产妇脐带血标本乙肝标志物,分析乙肝宫内感染情况。方法将HBsAg阳性产妇分为“HBsAg阳性、HBeAg阴性”组与“HBsAg阳性、HBeAg阳性”组,对其脐带血进行乙肝标志物检测。结果新生儿脐带血HBsAg阳性30例,宫内感染率7.8%,“HBsAg阳性、HBeAg阴性”孕产妇组新生儿宫内感染率4.9%,“HBsAg阳性、HBeAg阳性”孕产妇组新生儿宫内感染率16.0%,两组新生儿宫内感染率差异有统计学意义(χ2=12.75,P﹤0.01)。结论 “HBsAg阳性、HBeAg阳性”的孕产妇更容易发生宫内感染,应采取积极的治疗措施,以降低母婴传播的机率。
Objective To detect hepatitis B surface markers of hepatitis B surface antigen-positive umbilical cord blood samples, analysis of hepatitis B intrauterine infection. Methods HBsAg positive mothers were divided into “HBsAg positive, HBeAg negative” and “HBsAg positive, HBeAg positive” group, and their umbilical cord blood samples were tested for hepatitis B markers. Results Thirty newborns with cord blood HBsAg positive were found, the intrauterine infection rate was 7.8%, the rate of neonatal intrauterine infection was 4.9% in HBsAg positive, HBeAg negative, and HBsAg positive, HBeAg positive pregnant women The intrauterine infection rate of newborns was 16.0%. There was significant difference in intrauterine infection rates between the two groups (χ2 = 12.75, P <0.01). Conclusion “HBsAg-positive, HBeAg-positive” pregnant women are more likely to have intrauterine infection and aggressive treatment should be taken to reduce the chance of mother-to-child transmission.