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为了验证事件相关电位P3波幅降低是酒依赖的遗传标志的假说,作者在5个酒依赖高发家系32名18周岁以上成员(其中有14名酒依赖者)和8个无酒依赖的对照家系45名18周岁以上成员中采用Oddbal方法测查了听觉P3,结果发现,高发家系中的酒依赖者、非酒依赖者与对照家系成员之间的P3波幅和潜伏期差异均无统计学显著性。作者探讨了假说未得到验证的原因。
To verify the hypothesis that the event-related potential P3 amplitude reduction is a genetic marker of alcohol dependence, 32 of the five wine-dependent high-risk families were over 18 years old (of whom 14 were alcohol-dependent) and 8 were alcohol-dependent controls Oddbal method was used to examine auditory P3 in patients over 18 years old. The results showed that there was no significant difference in P3 amplitude and latency between alcohol dependent, non-alcohol dependent and control pedigrees in high prevalence families. The author explores why the hypothesis is unverified.