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目的探讨硬化剂注射联合奥曲肽治疗食管静脉曲张破裂出血的临床效果。方法 85例食管静脉曲张破裂出血患者,按随机数字表法分为对照组(42例)和观察组(43例)。对照组给予硬化剂治疗,观察组采用硬化剂联合奥曲肽治疗,比较两组患者止血时间、再出血、针眼出血、死亡情况及不良反应。结果观察组患者止血时间为(11.3±1.5)h,短于对照组患者的(16.2±3.7)h;观察组患者再出血1例,针眼出血3例,死亡0例,均少于对照组患者的7、15、4例;差异均有统计学意义(P<0.05)。观察组患者恶心1例,心悸1例,腹痛1例,不良反应发生率为6.98%;对照组恶心7例,头痛3例,不良反应发生率为23.81%;观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论硬化剂注射联合奥曲肽治疗食管静脉曲张破裂出血效果显著,可在临床中推广应用。
Objective To investigate the clinical effects of sclerotherapy combined with octreotide in the treatment of esophageal variceal bleeding. Methods Eighty-five patients with esophageal variceal bleeding were divided into control group (n = 42) and observation group (n = 43) according to random number table. The control group was treated with sclerotherapy. The observation group was treated with sclerotherapy and octreotide. The bleeding time, rebleeding, needle-eye bleeding, death and adverse reactions were compared between the two groups. Results The bleeding time in the observation group was (11.3 ± 1.5) h, which was shorter than that in the control group (16.2 ± 3.7) h. In the observation group, there was 1 case of rebleeding, 3 cases of needle-eye bleeding and 0 case of death, Of 7,15,4 cases; the difference was statistically significant (P <0.05). In the observation group, nausea in 1 case, palpitations in 1 case, abdominal pain in 1 case, adverse reaction rate was 6.98%. In the control group, nausea in 7 cases and headache in 3 cases, the incidence of adverse reactions was 23.81%. The incidence of adverse reactions in the observation group was lower than that in the control group Group, the difference was statistically significant (P <0.05). Conclusions Sclerotherapy injection combined with octreotide is effective in treating esophageal variceal bleeding and can be widely applied in clinical practice.