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寻找新的疗效高、副作用少的抗炎药物,以及恰当评价、合理使用目前各种药疗方法,是提高风湿类疾患治疗效果的重要措施。近些年来,国外对阿司匹林等常用抗炎镇痛药的药物动力学、剂型及剂量等方面,有一些新的见解;同时临床使用了不少新合成的、疗效较佳的抗炎镇痛药物。对甾体抗炎药的研究,已进入分子水平,就其抗炎效用的利弊,以及应用范围与使用方法,已经基本阐明。还发现右旋青霉胺、左旋咪唑等药可影响人体免疫,起非直接的抗炎效应,作用持久,已初步展现抗炎前景。本文综合介绍国外研究抗炎药物的近况及临床应用的经验。一、抗炎镇痛药抗炎镇痛药中,以应用广泛,适用于各种风湿类疾患的各个阶段,病程不超过半年者为佳。投给1次剂量所出现的镇痛效果与抗炎效应无关;抗风湿需要充足的剂量及足
Looking for new anti-inflammatory drugs with high efficacy and few side effects, as well as the proper evaluation and rational use of various current medical treatment methods, are important measures to improve the treatment effect of rheumatic diseases. In recent years, foreign countries such as aspirin and other commonly used anti-inflammatory analgesics pharmacokinetics, dosage forms and dosage, there are some new insights; at the same time the clinical use of many new synthetic, better efficacy of anti-inflammatory analgesic drugs . Research on steroidal anti-inflammatory drugs has entered the molecular level, and its pros and cons of anti-inflammatory effects as well as the scope of application and use of the method have been basically elucidated. Also found that dexamycin penicillamine, levamisole and other drugs can affect human immunity, play a direct anti-inflammatory effect, lasting effect, has shown an initial anti-inflammatory prospects. This article introduces the foreign research status of anti-inflammatory drugs and clinical experience. First, the anti-inflammatory analgesics Anti-inflammatory analgesics, to a wide range of applications, applicable to all stages of various rheumatic diseases, duration of no more than six months is better. The analgesic effect given to a single dose has nothing to do with anti-inflammatory effects; anti-rheumatism requires adequate doses and foot