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目的:利用灌注CT血容量图(blood volume,BV)评价兔VX2脑瘤模型大体靶区(gross tumor volume,GTV)/临床靶区(clinical target volume,CTV),并与病理对照。方法:对20只成功建模兔VX2脑瘤模型行灌注CT检查。测量脑瘤兴趣层面血容量(blood volume,BV)图最长径及最短径。并与其同层病理学大体靶区(GTV)、临床靶区(CTV)最长径及最短径对照。结果:20例GTV_(BV)图像显示长径大小为7.00 mm～18.30 mm,平均为11.98 mm±3.29 mm;短径为3.00 mm～10.60 mm,平均为7.03 mm±1.82 mm,同层GTV病理长径大小为3.00mm～12.00 mm,平均为7.98 mm±2.11 mm,短径为3.00 mm～8.00 mm,平均为4.40 mm±1.19 mm;CTV长径大小为5.10 mm～20.90 mm,平均为12.87 mm±3.74 mm,短径为4.40 mm～12.00 mm,平均为7.64 mm±2.05mm。GTV_(BV)与GTV_(病理)两两比较长短径方向有显著差异(P=0.000)。GTV_(Bv)与CTV_(病理)两两比较长径方向无显著差异(P=0.052);短径方向有显著差异(P=0.038)。利用GTV_(BV)评价脑瘤CTV长短径方向的外放范围分别为13.00%±14.00%,23.00%±27.00%。结论:CT灌注BV图像有用于脑瘤靶区勾画的潜力。
Objective: To evaluate the gross tumor volume (GTV) / clinical target volume (CTV) of rabbit VX2 brain tumor model by perfusion CT blood volume (BV). Methods: Twenty successful models of rabbit VX2 brain tumor were perfused with CT. Measurement of the level of interest in the brain tumor volume (blood volume, BV) Figure longest diameter and shortest diameter. And with the same pathological general target area (GTV), clinical target area (CTV) the longest diameter and the shortest diameter of the control. Results: The GTV BV images of 20 cases showed a long diameter of 7.00 mm to 18.30 mm with an average of 11.98 mm ± 3.29 mm, a short diameter of 3.00 mm to 10.60 mm, an average of 7.03 mm ± 1.82 mm, and a long GTV pathology Diameter of 3.00 mm to 12.00 mm with an average of 7.98 mm ± 2.11 mm, short diameter of 3.00 mm to 8.00 mm, an average of 4.40 mm ± 1.19 mm; CTV long diameter of 5.10 mm to 20.90 mm, an average of 12.87 mm ± 3.74 mm, short diameter of 4.40 mm ~ 12.00 mm, an average of 7.64 mm ± 2.05mm. GTV_ (BV) and GTV_ (pathology) had significant differences (P = 0.000) in the direction of longer axis and shorter axis. There was no significant difference in longitudinal diameter between GTV_ (Bv) and CTV_ (pathology) (P = 0.052), and significant difference in short axis (P = 0.038). Using GTV_ (BV) evaluation of brain tumor CTV long axis direction of the release range were 13.00% ± 14.00%, 23.00% ± 27.00%. Conclusion: CT perfusion BV images have potential for delineation of brain tumor target area.