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目的 :观察急性脑梗死血浆内血小板α 颗粒膜蛋白 14 0的动态变化 ,为选用抗血小板药物治疗提供依据。方法 :采用酶联免疫法 (ELISA法 )测定 5 0例急性脑梗死血浆内血小板α 颗粒膜蛋白 14 0 (GMP 14 0 ) ,同时检测血小板聚集功能 ,并进行动态观察。结果 :脑梗死组血浆GMP 14 0含量 ,急性期明显高于对照组 ,随后迅速下降 ,但至第 4周仍高于对照组。血小板聚集在急性期和恢复期均明显增高 ,急性期血浆GMP 14 0含量与有无糖尿病、高血压、冠心病等合并症无关 ,恢复期血浆GMP 14 0含量在重症患者明显高于轻症患者 ,且合并糖尿病患者血浆GMP 14 0含量持续下降 ,其含量与预后有关。结论 :脑梗死患者急性期血小板高度活化 ,血浆GMP 14 0比血小板聚集更具血小板活化的特异性 ,检测血浆GMP 14 0可作为估计病情和判断预后的指标。
Objective: To observe the dynamic changes of platelet α-granule membrane protein 140 in patients with acute cerebral infarction, and to provide the basis for choosing antiplatelet drugs. Methods: The plasma level of platelet α-membrane protein 14 0 (GMP 14 0) in 50 patients with acute cerebral infarction was measured by enzyme-linked immunosorbent assay (ELISA), and the platelet aggregation function was detected and dynamically observed. Results: The content of GMP 14 0 in acute cerebral infarction group was significantly higher than that in control group, then decreased rapidly, but still higher than that in control group by the 4th week. Platelet aggregation in acute phase and convalescent phase were significantly higher in acute phase plasma GMP 14 0 levels with or without diabetes, hypertension, coronary heart disease and other complications unrelated to convalescent plasma GMP 14 0 levels were significantly higher in critically ill patients than in patients with mild , And the plasma GMP 14 0 level in patients with diabetes mellitus continues to decline, and its content is related to the prognosis. CONCLUSION: In patients with acute cerebral infarction, the platelets are highly activated and the plasma GMP14 is more platelet-specific than platelet aggregation. Detecting plasma GMP14 can be used as an index to evaluate the prognosis and prognosis.