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目的：通过对40例肺癌患者红细胞免疫功能及T细胞亚群的同步测定，进一步了解肺癌患者的免疫状态。方法：设置肺癌组和正常对照组，同步检测RBC－Cb受体花环率、RBC－IC花环率及CD_3~+、CD_4~+、CD_8~+和4／8比值，并作相应比较。结果：肺癌组RBC－Cb受体花环率、CD_4~+．及4／8比值较正常对照组显著下降（P＜0．001和P＜0．01）；RBC－IC花环率、CD_3~+、CD_8~+无明显变化。结论：①肺癌患者同时存在红细胞免疫功能下降和T亚群失调；③上述改变属于原发性还是继发性，目前尚难定论；③在抗肿瘤治疗中，适时地使用免疫调节剂是值得推荐的。
OBJECTIVE: To further understand the immune status of lung cancer patients by the simultaneous measurement of red blood cell immune function and T cell subsets in 40 lung cancer patients. METHODS: Lung cancer group and normal control group were set up, and the RBC-Cb receptor rosette rate, RBC-IC rosette rate, and CD3+, CD4+, CD8+, and 4/8 ratios were simultaneously measured and compared. Results: RBC-Cb receptor rosette rate, CD_4~+ in lung cancer group. The 4/8 ratio was significantly lower than that in the normal control group (P<0.001 and P<0.01); there was no significant change in rosette rate, CD_3+, and CD8+ in RBC-IC. Conclusion: 1The patients with lung cancer have both the decline of red blood cell immune function and the imbalance of T subpopulation. 3 The above changes are either primary or secondary. It is still difficult to determine the conclusion; 3 In the anti-tumor therapy, the timely use of immunomodulators is worth recommending. of.