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采用ＩＩＦ和ＥＬＩＳＡ法分别检测了２２例尖锐湿疣（ＣＡ）患者和１６例正常对照者外周血淋巴细胞（ＰＢＬ）上膜白细胞介素２受体（ｍＩＬ－２Ｒ）表达水平及其培养上清中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）的含量，同时观察了卡介菌多糖核酸（ＢＣＧ－ＰＳＮ）在体外对这两项指标的影响。结果发现，患者ＰＢＬ上ｍＩＬ－２Ｒ表达下降，而培养上清中ｓＩＬ－２Ｒ含量明显增高；一定浓度的ＢＣＧ－ＰＳＮ能在体外使患者淋巴细胞ｍＩＬ－２Ｒ表达增强，以及降低培养上清中ｓＩＬ－２Ｒ的含量。这表明ＣＡ患者存在细胞免疫缺陷，ＢＣＧ－ＰＳＮ能在体外调节患者细胞免疫功能。
The expression of membrane interleukin 2 receptor (mIL-2R) on peripheral blood lymphocytes (PBLs) in 22 CA patients and 16 healthy controls were detected by ELISA and IIF respectively Soluble interleukin 2 receptor (sIL-2R), and to observe the effects of BCG-PSN on these two indexes in vitro. The results showed that the expression of mIL-2R in PBL decreased and the content of sIL-2R in the culture supernatant was significantly increased. A certain concentration of BCG-PSN could increase the expression of mIL-2R in lymphocytes in vitro and decrease the sIL -2R content. This suggests that cellular immune deficiency exists in CA patients and that BCG-PSN modulates cellular immune function in vitro.