论文部分内容阅读
目的:探讨内镜下氩离子凝固术(APC)联合埃索美拉唑治疗对Barrett食管(BE)的临床疗效。方法:选择经内镜及病理证实的52例BE患者,在内镜下行APC损毁化生黏膜治疗,再给予埃索美拉唑抑酸40mg/d口服8周。术后进行内镜、病理随访12个月。结果:52例均完成治疗,其中需要1次治疗者40例,2次者10例,3次者2例。49例达到完全的鳞状上皮再生(94.2%),3例再生的鳞状上皮间混有岛状的柱状上皮(5.8%)。12个月后共有5例出现内镜下可见的复发。结论:内镜下APC联合埃索美拉唑治疗BE简单、安全、有效,但有一定比例的残留和复发。
Objective: To investigate the clinical effect of endoscopic argon plasma coagulation (APC) combined with esomeprazole on Barrett’s esophagus (BE). Methods: Fifty-two patients with BE confirmed by endoscopy and pathology were treated with endoscopic APC for mucosa destruction and oral administration of esomeprazole 40 mg / d for 8 weeks. Endoscopic surgery, pathological follow-up of 12 months. Results: All of the 52 patients completed the treatment, of which 40 required 1 treatment, 10 were 2 and 3 were 2. 49 cases of complete squamous epithelium regeneration (94.2%), 3 cases of regenerated squamous epithelium with island-shaped columnar epithelium (5.8%). A total of 5 patients developed endoscopic re-exposure 12 months later. Conclusion: Endoscopic APC combined with esomeprazole in BE is simple, safe and effective, but there is a certain proportion of residual and recurrence.