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目的了解流行性乙型脑炎(乙脑)减毒活疫苗当前使用的两针免疫法的免疫效果。方法在广州市海珠区选取未接种过乙脑疫苗且未患过乙脑的8月龄~10月龄儿童,按当前8月龄始初免、24月龄始加强的程序先后进行两针次免疫,并于免疫前和免疫后1个月各采集静脉血(共4次)进行乙脑中和抗体检测。结果 176名儿童的初免前抗体阳性率为9.6%,抗体几何平均滴度(GMT)为1:1.27;初免后抗体阳性率为86.9%,GMT为1:19.35;至加强免疫前抗体阳性率降至75.0%,GMT降至1:9.38;加强免疫后抗体阳性率为96.0%,GMT为1:40.92;免疫后抗体应答强弱与免疫前抗体滴度高低呈负相关关系。结论我国当前使用的乙脑减毒活疫苗两针免疫法的免疫效果良好。
Objective To understand the immunological effects of the two-needle immunization currently used in live attenuated JE vaccines. Methods Eight-month-old to 10-month-old children who had not been vaccinated with Japanese encephalitis and who had not been vaccinated with Japanese encephalitis were enrolled in Haizhu District of Guangzhou City. According to the current initial 8-month-old and 24-month-old intensive procedures, Immunization, and venous blood was collected before immunization and 1 month after immunization (total 4 times) for detection of JE neutralizing antibody. Results The positive rate of preimmune antibody was 9.6%, the geometric mean antibody titer (GMT) was 1: 1.27, the positive rate of antibody after initial immunization was 86.9% and the GMT was 1: 19.35 The rate of GMT decreased to 1: 9.38; the positive rate of antibody after booster immunization was 96.0% and the GMT was 1: 40.92; The relationship between the antibody response after immunization and the antibody titer before immunization was negatively correlated. Conclusions The two-needle immunization method of live attenuated JE vaccine currently used in our country has a good immunization effect.