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目的探讨促性腺激素释放激素激动剂(GnRH-α)联合反向添加疗法对于行腹腔镜保守手术的卵巢子宫内膜异位囊肿的临床可行性。方法将2014年1月~2015年12月在潍坊市益都中心医院行腹腔镜保守手术的卵巢子宫内膜异位囊肿患者180例,随机分成3组,对照组58例术后不予任何治疗,实验A组65例,术后给予GnRH-α治疗,实验B组57例,术后给予GnRH-α联合利维爱反向添加治疗,比较3组治疗后的激素变化、不良反应和复发情况。结果实验A组雌二醇(E2)、黄体生成素(LH)下降较实验B组明显(P<0.05)。实验组产生不同程度副反应,如潮热、盗汗、骨痛,但是实验B组的发生率较实验A组低(P<0.05)。实验组复发率分别为10.77%,8.77%,较对照组(24.14%)低(P<0.05),但实验组间比较,复发率无统计学意义(P>0.05)。结论卵巢子宫内膜异位囊肿术后GnRH-α联合反向添加疗法在临床上是可行且有效的。
Objective To investigate the clinical feasibility of GnRH-α in combination with reverse addition therapy for ovarian endometriosis undergoing laparoscopic conservative surgery. Methods From January 2014 to December 2015, 180 cases of ovarian endometriosis undergoing laparoscopic conservative surgery in Yidu Central Hospital of Weifang City were randomly divided into three groups, 58 cases in the control group were treated with no treatment , Group A (n = 65) received GnRH-α after operation. Group B (n = 57) received GnRH-α combined with reverse addition of Levi after operation. The hormonal changes, adverse reactions and relapse . Results The estradiol (E2) and luteinizing hormone (LH) in experimental group A decreased significantly compared with that in experimental group B (P <0.05). The experimental group had different degrees of side effects such as hot flashes, night sweats, and bone pain, but the incidence of experimental group B was lower than that of experimental group A (P <0.05). The recurrence rates in the experimental group were 10.77% and 8.77%, respectively, which were lower than those in the control group (24.14%) (P <0.05). However, the relapse rate was not statistically significant between the experimental groups (P> 0.05). Conclusion GnRH-α combined with reverse addition therapy in ovarian endometriosis is clinically feasible and effective.