论文部分内容阅读
葡萄膜炎是青年患者视力障碍的一个常见原因。眼内炎的机理正得到更进一步的解释。前葡萄膜炎综合征,特别是有 HLA-B27反复的病,看来与革兰氏阴性菌细胞壁作为眼免疫反应外源的起始因子有很大关系。这一机理假设是由一个正常 T 细胞监视网路的旁路来介导的,伴之以 B 细胞增殖并引起抗体或免疫复合物介导的疾病。后葡萄膜炎看来与 T 细胞系统有更直接的联系。此外,某些后葡萄膜炎病例与视网膜的自身免疫有关,例如鸟枪弹伤样视网膜脉络膜病变。对于特异免疫反应的易感倾向来说,HLA 联合体可能是一种遗传标记或是作为一种膜抗原对引起眼内局部免疫反应起重要作用。外科治疗的方法无特别,往往是用类固醇或细胞毒素治疗。无论外科处理还是更特异的药物治疗,如环孢霉素,看来对本病治疗都有较大作用。
Uveitis is a common cause of visual impairment in young patients. The mechanism of endophthalmitis is being further explained. Anterior uveitis syndrome, especially with HLA-B27 recurrent disease, appears to have a strong relationship with the Gram-negative bacterial cell wall as an exogenous initiation factor for ocular immune responses. This mechanism is hypothesized to be mediated by the bypass of a normal T-cell surveillance network, accompanied by B cell proliferation and causing antibody or immune complex-mediated diseases. Post-uveitis appears to have a more direct connection with the T cell system. In addition, some cases of post-uveitis are associated with retinal autoimmunity, such as shotgun-like retinochoroidal lesions. For the predisposition to specific immune responses, the HLA association may be a genetic marker or an important role as a membrane antigen in eliciting local intraocular immune responses. Surgical treatment of no special, often with steroids or cytotoxic treatment. Whether surgical treatment or more specific drug treatment, such as cyclosporine, appears to have a greater effect on the treatment of this disease.