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神经肽Y(NPY)具有较强的缩血管作用 ,对心脏表现为负性肌力作用。它是通过突触后膜上特异的受体 ,对血管发挥收缩增强和舒张抑制作用 ,使总外周阻力增加和周围组织器官血流减少。心力衰竭时由于心输出量减少 ,NPY明显升高 ,NPY对心肌有剂量依赖性负性肌力作用 ,NPY含量越高 ,对心脏损害作用越大。降钙素基因相关肽 (CGRP)是体内最强的血管扩张剂 ,具有增加冠脉血流量和正性肌力作用 ,还可以通过降低血液粘稠度等因素改善血液流变学性质 ,抑制脂质过氧化的发生 ,防止蛋白和酶的漏出 ,有效阻止组织的缺血 /再灌注损伤和减少严重心律失常症发生频次。心衰时 ,血浆CGRP浓度的降低 ,使机体丧失了一个心血管系统的重要保护屏障。因此 ,在心衰期间适当应用NPY拮抗剂 ,有助于降低血管阻力 ,增加心输出量 ,有利于冠脉循环 ;应用CGRP可预防心肌细胞受损
Neuropeptide Y (NPY) has a strong vasoconstrictor effect, the performance of the negative cardiac muscle. It is through the postsynaptic membrane-specific receptors, the contraction of the blood vessels to play a role in systolic and diastolic, so that increased peripheral resistance and peripheral tissues and organs to reduce blood flow. Heart failure due to decreased cardiac output, NPY was significantly increased, NPY on the myocardial dose-dependent negative inotropic effect, the higher the NPY content, the greater the role of heart damage. Calcitonin gene-related peptide (CGRP) is the strongest vasodilator in the body, with increased coronary blood flow and positive inotropic effect, but also by reducing blood viscosity and other factors to improve blood rheology, inhibit lipid Peroxidation occurs, preventing the leakage of proteins and enzymes, effectively preventing tissue ischemia / reperfusion injury and reducing the incidence of severe arrhythmia. Heart failure, the plasma CGRP concentration decreased, the body lost an important protective barrier of the cardiovascular system. Therefore, the proper application of NPY antagonists during heart failure can help reduce vascular resistance and increase cardiac output, which is beneficial to coronary circulation; CGRP can prevent myocardial cell damage