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定义骨髓坏死是造血骨髓中组织和基质的大面积坏死,不包括造血机能无继发性改变的局灶性坏死和伴随于骨坏死的骨髓坏死。本症首先由Graham.G.S于1924年在镰状细胞贫血病人的尸检中发现,1941年Wade.L.J等在镰状细胞贫血的希腊妇女骨髓穿刺发现,以后陆续报道许多良、恶性疾病均可引起。发生率美国维吉尼亚大学医院在12年中经骨髓抽吸和/或活检发现13例骨髓坏死的病人,其发生率为1/664(0.15%)。Alabama和Birminghan两个大学医院对368例病人500例次骨髓活检,1/3有骨髓坏死或变性,其中肿瘤患者77/239例,非肿瘤患者43/129例。Nies.B.A等尸检316例白血病人,其发生率在急淋中为28/187例(15%),在急非淋中为4/124例(3%),不明类型的白血病为2/5例(40%),总发生
Definition Bone marrow necrosis is massive necrosis of tissues and matrices in hematopoietic marrow, excluding focal necrosis without secondary changes in hematopoietic function and bone marrow necrosis associated with osteonecrosis. The disease was first discovered by Graham.GS in an autopsy of patients with sickle cell disease in 1924. In 1941, Wade.LJ and other bone marrow punctures found in Greek women with sickle-cell anemia, and later reported many benign and malignant diseases can cause . The incidence of bone marrow necrosis was found in 13 patients who had undergone bone marrow aspiration and / or biopsy at the University of Virginia Hospital in the United States in 12 years. The incidence rate was 1/664 (0.15%). Two university hospitals in Alabama and Birminghan performed 500 subcutaneous bone marrow biopsies in 368 patients, with one third having necrosis or degeneration of the bone marrow, including 77/239 tumors and 43/129 non-tumor patients. The autopsy of 316 leukemic patients such as Nies.BA occurred in 28/187 (15%) of acute leaching, 4/124 (3%) in acute leprosy, and 2/5 of unidentified leukemia Cases (40%), always occur