【摘 要】
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Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier,leading to irreversible and substantial respiratory function dam-age.Patients with coronavirus disease 2019 (COVID-19) hav
【机 构】
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Tongji School of Pharmacy,Huazhong University of Science and Technology,Wuhan 430030,China;Tongji Sc
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Acute respiratory distress syndrome (ARDS) is characterized by the severe inflammation and destruction of the lung air-blood barrier,leading to irreversible and substantial respiratory function dam-age.Patients with coronavirus disease 2019 (COVID-19) have been encountered with a high risk of ARDS,underscoring the urgency for exploiting effective therapy.However,proper medications for ARDS are still lacking due to poor pharmacokinetics,non-specific side effects,inability to surmount pul-monary barrier,and inadequate management of heterogeneity.The increased lung permeability in the pathological environment of ARDS may contribute to nanoparticle-mediated passive targeting delivery.Nanomedicine has demonstrated unique advantages in solving the dilemma of ARDS drug therapy,which can address the shortcomings and limitations of traditional anti-inflammatory or antioxidant drug treat-ment.Through passive,active,or physicochemical targeting,nanocarriers can interact with lung epithe-lium/endothelium and inflammatory cells to reverse abnormal changes and restore homeostasis of the pulmonary environment,thereby showing good therapeutic activity and reduced toxicity.This article re-views the latest applications of nanomedicine in pre-clinical ARDS therapy,highlights the strategies for targeted treatment of lung inflammation,presents the innovative drug delivery systems,and provides inspiration for strengthening the therapeutic effect of nanomedicine-based treatment.
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