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目的:探讨肝癌患者血清中肿瘤标记物γ-谷氨酰转换酶同功酶Ⅱ(γ-GTⅡ)的表达及临床诊断价值。方法;采用γ-GTⅡ抗体,建立金标斑点法。检测原发性肝癌50例,转移性肝癌17例,肝硬化21例,慢活肝20例,慢迁肝22例,正常人40例。结果:对肝癌的敏感性83.5％,特异性93.2％。正常人全阴性。并发现γ-GTⅡ与肝癌大小、AFP含量没有相关性。结论:γ-GTⅡ对肝癌的检出有较高的敏感性和特异性,有助于肝癌的早期发现,同时,γ-GTⅡ抗体金标斑点法操作简便、快速,适合于临床辅助诊断和人群筛检。
Objective: To investigate the expression and clinical value of tumor marker γ-glutamyltransferase isoenzyme II (γ-GTII) in serum of patients with hepatocellular carcinoma. Methods; Using γ-GTII antibody, establish gold labeling method. There were 50 cases of primary hepatocellular carcinoma, 17 cases of metastatic liver cancer, 21 cases of liver cirrhosis, 20 cases of slow-moving liver, 22 cases of slow-moving liver, and 40 cases of normal. Results: Sensitivity to liver cancer was 83.5% and specificity was 93.2%. Normal people are completely negative. It was found that there was no correlation between γ-GTII and liver cancer size and AFP content. Conclusion: γ-GTII has high sensitivity and specificity for the detection of liver cancer, which is helpful for the early detection of liver cancer. At the same time, γ-GTII antibody gold labeling method is simple, rapid and suitable for clinical diagnosis and population. Screening.