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目的了解东太湖地区女性高危人乳头状瘤病毒(HPV)感染基因亚型的分布情况,为宫颈癌的防治提供理论依据。方法选用基因芯片技术检测3 544例妇女的23种HPV基因亚型分布情况。结果 3 544例妇女中,除6例患者因镜检宫颈上皮细胞阴性被排除外,其余3 538例患者均被统计在内。HPV阳性患者748例,感染率为21.14%,其中单一感染550例,多重感染198例。不同年龄患者的HPV总感染率比较差异有统计学意义(P<0.05)。女性HPV感染中,最普遍的型别为HPV52、HPV16、HPV58和HPV18。多重感染中,HPV58/33和HPV58/52的组合最多见。结论 50岁以上为宫颈癌高发年龄,应定时进行体检筛查,有助于更好地开展当地宫颈癌防治工作。
Objective To understand the distribution of high risk human papillomavirus (HPV) infection in the East Taihu Lake region and to provide a theoretical basis for the prevention and treatment of cervical cancer. Methods The gene chip technique was used to detect the distribution of 23 HPV subtypes in 3 544 women. Results Of 3 544 women, 3 538 of the remaining 3 538 patients were excluded, except 6 patients who were negative for cervical microscopy. 748 cases of HPV-positive patients, the infection rate was 21.14%, of which 550 cases of single infection, multiple infections in 198 cases. The HPV infection rates of patients of different ages had significant difference (P <0.05). The most common types of HPV infection in women are HPV52, HPV16, HPV58 and HPV18. In multiple infections, the most common combination of HPV58 / 33 and HPV58 / 52. Conclusions Age over 50 years old is the high incidence of cervical cancer, physical examination should be regularly scheduled to help better carry out local prevention and treatment of cervical cancer.