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本研究分别观察了DBA/2J(简称D_2)和C_(57)B4/6(简称B_6)小鼠在噪声中癫痫样发作的诱发得分及脑干区Ca~(2+)-ATP酶的活性.结果发现,D_2组噪声诱发得分显著高于B_6组,而脑干区Ca~(2+)-ATP酶活性明显低于B_6组,D_2与B_6杂交后代的发作得分显著低于B_2,与B_6相似;Ca~(2+)-ATP酶活性介于D_2与B_6之间.说明癫痫样发作与遗传有关,其遗传方式符合多基因遗传.对D_2组内有癫痫样发作及无癫痫样发作小鼠Ca~(2+)-ATP酶活性的统计学处理表明两者差异有显著性.进一步证实Ca~(2+)-ATP酶对D_2小鼠的癫痫遗传易患性起决定性作用.
In this study, we observed the induction of epileptic seizures and the activity of Ca ~ (2 +) - ATPase in brainstem in DBA / 2J (D_2) and C_ (57) B4 / 6 The results showed that the noise - induced scores of D_2 group were significantly higher than those of B_6 group, while the Ca ~ (2 +) - ATPase activity of brain stem area was significantly lower than that of B_6 group, and the seizure scores of D_2 and B_6 were significantly lower than that of B_2 and B_6 Similar to the control group.The activity of Ca ~ (2 +) - ATPase was between that of D_2 and B_6, indicating that the epileptic seizure was related to heredity and the genetic mode was consistent with polygenetic inheritance.Depression of epileptic seizures and absence of epileptiform seizure The statistical analysis of the Ca ~ (2 +) - ATPase activity showed that there was a significant difference between the two groups, further confirming that Ca ~ (2 +) - ATPase plays a decisive role in the genetic predisposition of epilepsy in D_2 mice.