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目的:观察雷贝拉唑与法莫替丁联合治疗胃食管反流病(GERD)的疗效。方法:GERD患者89例随机分为治疗组(n=45)和对照组(n=44),两组每天早、晚餐前均服雷贝拉唑10mg,治疗组夜间睡前另加服法莫替丁20mg,疗程6周。治疗前及疗程结束后行胃镜检查,观察其胃镜表现及反流症状的改善程度。结果:治疗组45例中治愈31例,有效12例,无效2例,总有效率达95.6%(43/45),对照组44例中治愈22例,有效13例,无效9例,总有效率79.5%(35/44)。结论:雷贝拉唑与法莫替丁联合治疗GERD的疗效优于单用雷贝拉唑者。
Objective: To observe the efficacy of rabeprazole combined with famotidine in the treatment of gastroesophageal reflux disease (GERD). Methods: Eighty-nine patients with GERD were randomly divided into treatment group (n = 45) and control group (n = 44). Both groups were given rabeprazole 10mg daily before breakfast and evening meal. For Ding 20mg, treatment for 6 weeks. Before treatment and after the end of the course of gastroscopy, to observe the performance of gastroscopy and improvement of reflux symptoms. Results: In the treatment group, 31 cases were cured in 45 cases, 12 cases were effective and 2 cases were ineffective. The total effective rate was 95.6% (43/45). In the control group, 22 cases were cured in 44 cases, 13 cases were effective, 9 cases were ineffective, Efficiency 79.5% (35/44). Conclusion: The combination of rabeprazole and famotidine in the treatment of GERD is better than rabeprazole alone.