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目的:研究人胃癌组织生长激素受体(GHR)的表达情况及其与肿瘤临床病理特点的关系。方法:回顾性分析100例胃癌病人资料,采用免疫组化法检测组织的GHR表达,分析其与肿瘤分化程度、病理分期、Borrmann分型的关系。同时检测其中14例癌旁正常胃黏膜组织的GHR表达情况,分析正常胃黏膜与肿瘤组织GHR表达的差异。结果:胃癌组织中GHR表达阳性率为55%(55/100),正常组织为85.7%(12/14)。GHR表达与临床分期、组织分化程度显著相关(P<0.01),与Borrmann分型相关(P<0.05)。GHR表达与肿瘤发生部位、性别和年龄均无相关性。结论:胃癌组织中GHR的表达存在差异。
Objective: To study the expression of growth hormone receptor (GHR) in human gastric carcinoma and its relationship with clinicopathological features. Methods: The data of 100 patients with gastric cancer were retrospectively analyzed. The expression of GHR was detected by immunohistochemistry. The relationship between the expression of GHR and tumor differentiation, pathological stage and Borrmann classification was analyzed. At the same time, GHR expression in 14 adjacent normal mucosa tissues was detected, and the difference of GHR expression between normal gastric mucosa and tumor tissue was analyzed. Results: The positive rate of GHR expression in gastric cancer tissues was 55% (55/100) and that in normal tissues was 85.7% (12/14). The expression of GHR was significantly associated with clinical stage and histological differentiation (P <0.01), which was correlated with Borrmann classification (P <0.05). GHR expression and tumor location, gender and age were not related. Conclusion: The expression of GHR in gastric cancer tissue is different.