论文部分内容阅读
目的 评价抗杀菌渗透性增强蛋白抗体 (BPI)临床意义。方法 应用纯化的BPI抗原 ,以酶联免疫吸附方法 (ELISA)检测 410份病人血清抗BPI抗体 ,免疫印迹法验证部分阳性血清 ,分析临床资料。结果 47例抗BPI阳性。临床肺部疾病 18例 ,包括 10例慢性支气管炎 ;7例系统性红斑狼疮 ;5例溃疡性结肠炎 ;3例原发性小血管炎及其它。肺部炎症病变及血管炎的 2 1例病人中 9人合并呼吸道绿脓肝菌感染。结论 抗BPI自身抗体可见于慢性肺部炎症性疾病和自身免疫性疾病 ,其临床意义有待于进一步阐明。
Objective To evaluate the clinical significance of bactericidal osmotic enhanced protein antibody (BPI). Methods The purified anti-BPI antigen was used to detect the serum anti-BPI antibody in 410 patients by enzyme-linked immunosorbent assay (ELISA). The positive serum was verified by immunoblotting and the clinical data were analyzed. Results 47 cases of anti-BPI positive. Clinical lung disease in 18 cases, including 10 cases of chronic bronchitis; 7 cases of systemic lupus erythematosus; 5 cases of ulcerative colitis; 3 cases of primary small vessel vasculitis and others. Nineteen of 21 patients with pulmonary inflammatory disease and vasculitis were infected with P. aeruginosa. Conclusion Anti-BPI autoantibodies can be found in chronic lung inflammatory diseases and autoimmune diseases, and its clinical significance needs to be further elucidated.