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目的:观察盐酸曲美他嗪对急性病毒性心肌炎的心肌保护作用。方法:选择符合成人急性病毒性心肌炎诊断标准的患者86例,随机分为治疗组(40例)和对照组(46例)。两组患者均卧床休息,应用抗生素、激素综合治疗,而治疗组在综合治疗基础上加用盐酸曲美他嗪片口服治疗。治疗前后采患者静脉血检测CK、CK-MB、肌钙蛋白I、血沉(ESR)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)等指标。结果:盐酸曲美他嗪治疗组治疗后CK、CK-MB、肌钙蛋白I、hs-CRP及TNF-α等指标水平均比对照组低(P<0.05);仅ESR结果无显著差异。结论:盐酸曲美他嗪对急性病毒性心肌炎的心肌有很好的保护作用。
Objective: To observe the myocardial protective effect of trimetazidine hydrochloride on acute viral myocarditis. Methods: A total of 86 patients with acute viral myocarditis were selected and randomly divided into treatment group (40 cases) and control group (46 cases). Both groups were rest in bed, antibiotics, hormones combined treatment, while the treatment group on the basis of comprehensive treatment with trimethoprim hydrochloride tablets oral treatment. Serum CK, CK-MB, ESR, hs-CRP and TNF-α were measured before and after treatment. Results: The levels of CK, CK-MB, troponin I, hs-CRP and TNF-α in the trimetazidine hydrochloride treatment group were lower than those in the control group (P <0.05); only the ESR showed no significant difference. Conclusion: Trimetazidine hydrochloride has a good protective effect on myocardium of acute viral myocarditis.