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山莨菪碱是以我国茄科植物唐古特莨碱提成的生物碱,现已人工合成,具有阿托品类似的作用而稍弱。与阿托品相比,抑制腺体分泌和扩瞳作用较弱,且不易透过血脑屏障,故少有中枢副作用。其天然品称“654-1”,人工合成产品称“654-2”。近年来,654-2在临床应用上由于对血管的扩张作用而日益广泛,成为临床常用药物之一。
Anisodamine is an alkaloid extracted from Solantheide, a solanaceous plant in China. It has been artificially synthesized and has a similar effect and is slightly weaker than atropine. Compared with atropine, the inhibition of glandular secretion and pupil dilation is weak, and it is not easy to penetrate the blood-brain barrier, so there are few central side effects. Its natural product is called “654-1” and its artificial product is called “654-2”. In recent years, 654-2 has become more and more widely used in clinical applications due to the expansion of blood vessels, and has become one of the commonly used drugs in clinical practice.