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目的:探讨血浆和心肌肉皮素在实验性多器官功能不全综合征(MODS)家兔急性期中的变化及其意义;方法:用肠系膜上动脉结扎肠缺血制备MODS,采用放免标记法测定血和心肌中内皮素水平,电镜下观察心肌细胞组织形态学改变;结果:实验组与对照组比较,6h即有显著差异,12h仍有变化,24h差异显著,此时心肌细胞损伤最严重;结论:内皮素可能参与了MODS的发生和发展过程,是一个重要的相关因素.
Objective: To investigate the changes and significance of plasma and myocardial angiotensin in experimental acute multiple organ dysfunction syndrome (MODS) in rabbits.Methods: MODS were prepared by ligating the superior mesenteric artery with intestinal ischemia, and the levels of blood and The level of endothelin in myocardium was observed by electron microscope. The morphological changes of myocardial cells were observed under electron microscope. Results: Compared with the control group, there was significant difference at 6h and 12h, Endothelin may be involved in the occurrence and development of MODS, which is an important relevant factor.