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用海人草酸毁损大鼠苍白球造成老年性痴呆模型并在海马，额皮层。纹状体及延髓脑桥部四个不同胞区测定了单胺递质水平的变化。在此模型中，大鼠海马和额皮层的去甲肾上腺素（ＮＥ）水平显著低于正常对照，说明在以上脑区去甲肾上腺素能神经已遭损伤。多巴胺（ＤＡ）水平在四个脑区均有所降低，其中在额皮层和纹状体降低显著，同时在大脑额皮层，纹状体和延髓脑桥部，ＤＡ转化率均显著降低。结果提示，在此模型中，ＤＡ代谢可能出现紊乱。５羟色胺水平和多巴胺－β－羟化酶（ＤＢＨ）活性（用ＮＥ／ＤＡ的比率表示）同正常对照相比无显著性差异。结果显示此模型基本上反映了老年性痴呆病人脑中单胺递质水平的变化，可以作为老年性痴呆模型用于基础医学与治疗研究。
Oxidative damage to the rat globus pallidus caused by Alzheimer’s disease caused a model of Alzheimer’s disease in the hippocampus and frontal cortex. The changes of monoamine neurotransmitters were measured in four different regions of the striatum and medulla oblongata. In this model, norepinephrine (NE) levels in the hippocampus and frontal cortex of rats were significantly lower than those of the normal controls, indicating that noradrenergic nerves were damaged in the above brain regions. Dopamine (DA) levels decreased in all four brain regions, with a significant decrease in the frontal cortex and striatum, and a significant decrease in DA conversion in the cerebral frontal cortex, striatum and medulla oblongata. The results suggest that in this model, DA metabolism may be disturbed. Serotonin levels and dopamine-β-hydroxylase (DBH) activity (expressed as NE / DA ratio) showed no significant difference from the normal control. The results show that this model basically reflects the change of monoamine neurotransmitters in the brain of Alzheimer’s disease patients and can be used as a model of Alzheimer’s disease in the study of basic medicine and treatment.