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目的通过检测2型糖尿病患者血清C-反应蛋白(CRP)浓度,探讨2型糖尿病患者血清CRP的检测意义。方法以2002年参加开滦(集团)有限责任公司干部健康查体的离退休员工2 209人为研究人群;通过问卷调查了解参检者的健康信息,检测空腹血糖、血清CRP浓度等相关生化指标,比较2型糖尿病患者与非糖尿病患者血清CRP浓度差异及其高血压、冠心病、脑卒中的患病率。结果 2型糖尿病组血清CRP浓度明显高于非糖尿病组血清CRP浓度(16.19±16.53vs11.62±11.56)mmol/L,且差异有统计学意义(P<0.05);其高血压、冠心病、脑卒中患病率明显高于非糖尿病组(49.1%vs39.0%,27.0%vs16.4%,14.2%vs8.8%)。结论血清CRP浓度与2型糖尿病患者空腹血糖水平呈正相关,血清hs-CRP水平检测对2型糖尿病及其血管病变的早期诊断和病情分析有着重要的临床价值。
Objective To detect serum C-reactive protein (CRP) levels in type 2 diabetic patients to explore the significance of serum CRP in type 2 diabetic patients. Methods A total of 2 209 retired employees participated in the health examination of cadres in Kailuan (Group) Co., Ltd in 2002. The questionnaires were used to understand the health information, the fasting blood glucose, the serum CRP concentration, The difference of serum CRP levels between type 2 diabetic patients and non-diabetic patients was compared with the prevalence of hypertension, coronary heart disease and stroke. Results Serum CRP levels in type 2 diabetic patients were significantly higher than those in non-diabetic patients (16.19 ± 16.53 vs 11.62 ± 11.56) mmol / L, and the difference was statistically significant (P <0.05). The patients with hypertension, coronary heart disease, The prevalence of stroke was significantly higher in non-diabetic subjects (49.1% vs 39.0%, 27.0% vs 16.4%, 14.2% vs 8.8%). Conclusion Serum CRP concentration is positively correlated with fasting blood glucose level in type 2 diabetic patients. Detection of serum hs-CRP level has important clinical value in early diagnosis and condition analysis of type 2 diabetes mellitus and its vascular diseases.