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目的:探讨常规体外受精-胚胎移植(IVF-ET)后胚胎停育患者绒毛染色体异常的相关影响因素。方法:回顾性分析IVF-ET后胚胎停育的61个周期,按绒毛染色体单核苷酸多态性(SNP)分子核型检测结果分为分子核型正常组(A组)和分子核型异常组(B组),分析比较A、B组间对象的临床特征及实验室指标等。结果:未限制年龄时,女方BMI、流产次数、COH次数、不孕年限、女方基础FSH、Gn用量及获卵数A、B组间差异均无统计学意义(P>0.05),A组男方年龄、女方年龄、移植胚胎数小于B组,差异均有统计学意义(P<0.05),正常形态精子比率、头部缺陷精子比率、颈部和中段缺陷精子比率、尾部缺陷精子比率、胞质水滴缺陷精子比率、畸形精子症比例组间均无统计学差异(P>0.05)。女方年龄<35岁时,A、B组间上述各指标差异均无统计学意义(P>0.05)。结论:女方年龄与IVF-ET后绒毛染色体异常有关,精子形态学指标对IVF-ET后胚胎停育患者绒毛染色体分子核型检测结果无预测价值。
Objective: To investigate the related factors of chromosomal abnormalities in chorionic villi after routine in vitro fertilization-embryo transfer (IVF-ET). Methods: Sixty-one cycles of embryo shutdown after IVF-ET were retrospectively analyzed. According to the karyotype of chorionic villous chromosome single nucleotide polymorphisms (SNP), the karyotypes were divided into normal group (A group) and molecular karyotype Abnormal group (group B), analysis and comparison of clinical characteristics and laboratory indicators between A and B groups. Results: There was no significant difference in BMI, miscarriage frequency, number of COH, duration of infertility, FSH, Gn dosage and the number of oocytes retrieved between groups A and B (P> 0.05) The age, the age of the female and the number of embryos transferred were smaller than those in the B group (P <0.05). The ratio of normal spermatozoa, sperm ratio in head, sperm ratio in neck and midbrain, sperm ratio in tail, There was no significant difference between the percentage of sperm defect of water drop and the percentage of spermosis (P> 0.05). When the female’s age was less than 35 years old, there was no significant difference between the above indexes in group A and group B (P> 0.05). CONCLUSION: The age of the woman is related to the abnormalities of the chorionic villi after IVF-ET. The results of sperm morphological analysis showed no predictive value for the karyotype analysis of chorionic villi in patients with IVF-ET embryo stop.