论文部分内容阅读
目的:研究PF诱导化疗联合调强放疗及二维放疗对鼻咽癌近远期疗效影响的回顾性分析。方法:将我院收治的30例鼻咽癌患者治疗情况,按照治疗方案不同分为观察组和对照组,观察组患者给予PF诱导化疗联合调强放疗治疗,对照组给予PF诱导化疗联合二维放疗治疗。比较两组临床疗效,随访近、远期毒副反应等情况。结果:观察总缓解率93.33%与对照组60.00%比较差异有统计学意义(P<0.05)。观察组Ⅲ-Ⅳ级胃肠道反应26.67%及黏膜炎13.33%发生率与对照组比较显著较少,差异有统计学意义(P<0.05)。结论:PF诱导化疗联合调强放疗治疗鼻咽癌患者,近远期临床疗效好,毒副反应少。
Objective: To investigate the effect of PF-induced chemotherapy combined with intensity-modulated radiotherapy and two-dimensional radiotherapy on the short-term and long-term effects of nasopharyngeal carcinoma. Methods: The treatment of 30 cases of nasopharyngeal carcinoma patients treated in our hospital were divided into observation group and control group according to different treatment plans. Patients in observation group were treated with PF induction chemotherapy combined with intensity modulated radiotherapy. In control group, PF induction chemotherapy combined with two-dimensional Radiotherapy treatment. The clinical efficacy, follow-up, long-term toxicities and side effects were compared between the two groups. Results: The total response rate was 93.33% and the control group 60.00% difference was statistically significant (P <0.05). The incidence of class Ⅲ-Ⅳ gastrointestinal tract reaction in observation group was 26.67%, and the incidence of mucositis was 13.33%. There was a significant difference between the observation group and the control group (P <0.05). Conclusion: PF induction chemotherapy combined with intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma, short-term clinical curative effect is good, less toxic side effects.