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阑尾切除术后感染很常见,而在结肠细菌中,厌氧菌占90％以上,故自70年代以来,厌氧菌感染日益受到了重视。为此,我院对198例急性阑尾炎手术治疗者,使用灭滴灵与安慰剂进行双盲、随机分组、前瞻性研究,现报道如下。一、资料与方法:所用灭滴灵(以下简称为M)与安慰剂(以下简称为P)均先袋装,分别以铅笔编号为M_(1、2、…100)及P_(1、2…100),混和后以钢笔随机编号为1、2、……200,将铅笔编号与钢笔编号记录于对照表中,此表封存于信封内,擦去药品袋上铅笔编号。然后按患者住院先后依次取用药品袋并在病历卡上记下钢笔编号,额满后开启对照表的信封核定患者为M组或P组,然后进行分析。凡临床确诊为急性阑尾炎而需手术者在准备手术区皮肤时,直肠内给予含灭滴灵0.5g的栓剂2颗(P组中的灭滴灵均代
Appendectomy infection is common, and in colon bacteria, anaerobic bacteria account for more than 90%, so since the 1970s, anaerobic infections have received increasing attention. To this end, our hospital 198 cases of acute appendicitis surgery, the use of metronidazole and placebo for double-blind, randomized, prospective study is now reported below. MATERIALS AND METHODS: The tablets of metronidazole (hereinafter referred to as M) and placebo (hereinafter referred to as P) were all sachet. Each pencil was numbered M_ (1, 2, ... 100) and P_ ... 100), mix the pen randomly numbered 1, 2, ... 200, the pencil number and pen number recorded in the table, the table sealed in the envelope, wipe the pencil bag number on the drug bag. Then according to the patient inpatient successively access to the drug bag and record the pen number in the medical record card, open the full list of patients after checking the envelope for the M group or P group, and then analyzed. Where clinically diagnosed as acute appendicitis and surgery required in the preparation of the operation area of the skin, given intramuscular suppository containing metronidazole 0.5g (P group metronidazole in the generation