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谷氨酸-组氨酸-赖氨酸(GHK)存在于人血液、唾液、尿液中，具有多种生物学作用。据目前知识所知，这些作用都是对健康有益的。其可促进伤口愈合和组织再生，抗炎、抗氧化，还可增加胶原蛋白、弹力蛋白和糖胺聚糖的合成。目前已经证明GHK可以作为治疗性成分在慢性阻塞性肺疾病和代谢性癌症中应用。本文主要关注GHK在呼吸系统疾病中的应用进展，为进一步实验研究及指导临床奠定基础。“,”Glycyl-histidyl-lysine (GHK) exists in human blood, saliva and urine, and has various biological functions.According to current knowledge, these effects are beneficial to health.It can promote wound healing and tissue regeneration, have anti-inflammatory and antioxidation, increase the synthesis of collagen, elastin and glycosaminoglycans.It has been proved that GHK can be used as a therapeutic component in treatment of chronic obstructive pulmonary disease and metabolic cancer.This article focuses on the development of GHK in respiratory diseases, laying a foundation for further experimental research and clinical guidance.