全固态乌头碱电化学检测器的研制及其在流动注射分析中的应用

• 作 者: 刘万忠 左阿玲
• 机 构: 湖北省药品检验所,湖北省药品检验所 武汉 430064,武汉 430064
• 出 处: 药学学报
• 发表日期: 1992年04期
• 关键词: 乌头碱 电化学检测器 流动注射分析 水解动力学 小活络丸 苯甲酰乌头碱 双酯型生物碱 固态 速度常数 生物碱

报道一种新型结构的全固态乌头碱电化学检测器的研制及其在流动注射分析中的应用。采用流动注射分析法对川乌、草乌及其中成药(小活络丸)中剧毒成分(双酯型生物碱)进行了测试,方法简便快速,结果同光度法接近。本文还提出了电化学法研究乌头碱水解动力学原理。在pH 6.5,温度98℃的条件下测得乌头碱水解成苯甲酰乌头碱的速度常数为1.36×10~(-2)min~(-1)。

The development of a new type of solid-state aconitine electrochemical detector and its application in flow injection analysis are reported. Flow-injection analysis was used to test the highly toxic components (dual-ester alkaloids) of Chuanwu, Caowu and its proprietary Chinese medicine (Xiaohuolou Pills). The method was simple and rapid, and the results were close to the photometric method. This paper also proposes electrochemical method to study the hydrolysis kinetics of aconitine. The rate constant for the hydrolysis of aconitine to benzoylaconitine was 1.36×10 -2 min -1 measured at pH 6.5 and 98°C.