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有确切输血史、血丙肝抗体及核酸均阳性的５０例急、慢性丙肝（急性肝炎２２例、慢性肝炎２３例、肝炎肝硬变５例）患者的唾液、尿液及精液中的ＨＣＶ－ＲＮＡ（ＰＣＲ）检测的阳性率分别为９００％、５００％及６００％。５例肝炎肝硬变患者均并发腹水，２例尚合并胸水，检测腹水８例次、胸水３例次，ＨＣＶ－ＲＮＡ均阳性。１例行胆道造瘘术的急性丙肝患者瘘管中流出的胆汁检测ＨＣＶ－ＲＮＡ阳性。２例患者于急性肝炎期，唾液ＨＣＶ－ＲＮＡ阴性，随病情的演变，转变为慢性肝炎后，再次检测，转呈阳性。３例病程在２年以上的男性慢性丙肝患者精液中检出丙肝核酸，采集其女性配偶的血液、唾液和尿液，ＨＣＶ－ＲＮＡ均阳性，血抗－ＨＣＶ亦阳性。该组急性丙肝中７例（２７２％）患者，于入院之初，血抗－ＨＣＶ阴性，而唾液ＨＣＶ－ＲＮＡ阳性。说明部分急性丙肝的早期，唾液中ＨＣＶ－ＲＮＡ的出现，早于血抗－ＨＣＶ。
HCV-RNA in saliva, urine and semen of 50 patients with acute and chronic hepatitis C (22 acute hepatitis, 23 chronic hepatitis and 5 cirrhosis) with positive blood transfusion history, positive serum HCV antibody and nucleic acid (PCR) test positive rates were 90 0%, 50 0% and 60 0%. Five patients with cirrhosis of liver were complicated with ascites, two with pleural effusion, eight ascites and three pleural effusion with positive HCV-RNA. One patient with acute cholangiostomy had a positive HCV-RNA in the bile from the fistula. Two patients in acute hepatitis, salivary HCV-RNA negative, with the evolution of the disease, converted to chronic hepatitis, re-test, positive transfusion. 3 cases of hepatitis C nucleic acid were detected in the semen of 2 years or more of chronic hepatitis C patients. The blood, saliva and urine of the female spouses were collected. The HCV-RNA was positive and the blood anti-HCV was also positive. In the group of 7 patients (27.2%) with acute hepatitis C, blood anti-HCV was negative and saliva HCV-RNA was positive at the beginning of admission. Explain the early part of the acute hepatitis C, the emergence of HCV-RNA in saliva, earlier than the blood anti-HCV.