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目的探讨急性一氧化碳中毒患者血浆一氧化氮(NO)含量与迟发性脑病的关系。方法将62例急性CO中毒患者分为两组:迟发性脑病组(A组)29例和未发生迟发性脑病组(B组)33例。采用检测NO的中间代谢产物亚硝酸盐来反映A、B两组患者连续血浆的NO水平,并与正常对照组进行比较。结果A、B两组中毒后第1天血浆NO含量均明显低于正常对照组(P<0.01,P<0.05),A、B组第5天血浆NO含量均明显低于正常对照组(P<0.05),A组第10天血浆NO含量明显低于B组、正常对照组(P<0.05)。结论动态观察急性一氧化碳中毒后病人血浆NO变化有助于预测迟发性脑病的发生。
Objective To investigate the relationship between plasma nitric oxide (NO) level and delayed encephalopathy in patients with acute carbon monoxide poisoning. Methods Sixty-two patients with acute CO poisoning were divided into two groups: 29 in delayed encephalopathy group (A group) and 33 in delayed encephalopathy group (B group). Nitrite, an intermediate metabolite of NO, was used to detect continuous plasma NO levels in patients A and B, and compared with normal control group. Results The levels of plasma NO in group A and group B were significantly lower than those in control group on the first day (P <0.01, P <0.05), while the level of NO in group A and B on day 5 was significantly lower than that of the control group <0.05). The content of NO in group A on day 10 was significantly lower than that in group B and the normal control group (P <0.05). Conclusions Dynamic observation of plasma NO in patients with acute carbon monoxide poisoning is helpful to predict the occurrence of delayed encephalopathy.