论文部分内容阅读
目的了解南阳市男男性行为(MSM)人群艾滋病病毒(HIV)新发感染情况及影响因素。方法采用动态队列研究的方法,于2010-2011年间建立MSM队列,对入组时HIV抗体阴性者每半年随访1次,收集HIV检测结果及其行为学信息。采用Cox比例风险模型进行HIV新发感染的单因素和多因素分析。结果南阳市429例MSM队列成员中,有20例新发HIV感染,2010-2011年总的HIV新发感染率(发病密度)为3.41/100人年。两年间4次随访的HIV新发感染率有所上升,依次为2.06/100人年、0.71/100人年、3.44/100人年和6.29/100人年。Cox回归多因素分析表明,少数民族[相对危险度(RR):4.91,95%可信区间(CI):1.04～23.17,P=0.04]、月收入≥2 000元(RR:7.99,95%CI:2.01～31.77,P<0.01)、性取向为同性(RR:3.16,95%CI:1.09～9.14,P=0.03)、近半年与男性发生肛交性行为从未使用安全套(RR:4.96,95%CI:1.10～22.42,P=0.04),是当地MSM人群HIV新发感染的影响因素。结论南阳市MSM人群HIV新发感染呈上升趋势,今后应考虑加强以关注同志场所和安全套使用为主的干预措施。
Objective To understand the new HIV infection and its influencing factors among MSM in Nanyang City. Methods By means of dynamic cohort study, MSM cohort was established between 2010 and 2011. HIV-negative patients were followed up once every six months to collect HIV test results and behavioral information. Univariate and multivariate analysis of new HIV infection using Cox proportional hazards model. Results Among the 429 MSM cohorts in Nanyang City, 20 cases were newly infected with HIV. The total new HIV infection rate (incidence density) in 2010-2011 was 3.41 / 100 person-years. The rates of new HIV infections at four follow-up visits during the two-year period increased by 2.06 / 100 person-years, 0.71 / 100 person-years, 3.44 / 100 person-years and 6.29 / 100 person-years respectively. Cox regression multivariate analysis showed that minority [relative risk (RR): 4.91, 95% confidence interval (CI): 1.04-23.17, P = 0.04] and monthly income ≥2 000 (RR: 7.99, 95% (RR: 3.16, 95% CI: 1.09 ~ 9.14, P = 0.03). In the past six months, condoms were never used in anal sex with men (RR: 4.96, P < 95% CI: 1.10-22.42, P = 0.04) were the influencing factors of new HIV infection in local MSM population. Conclusion The prevalence of HIV infection in MSM population in Nanyang City is on the rise. In the future, we should consider strengthening interventions focused on the use of gay places and condom use.