Rab proteins implicated in lipid storage and mobilization

• 作 者: Robert Scott Kiss Tommy Nilsson
• 机 构: Department of Medicine,McGill University,Research Institute of McGill University Health Centre,
• 出 处: The Journal of Biomedical Research
• 发表日期: 2014年03期
• 关键词: mobilization lipid implicated cytosolic hydrolysis subsequent cycling intracellu

INTRODUCTION Rab proteins are cytosolic small molecule GTPases that are recruited to the cytosolic leaflet of intracellular membranes where they function in various cellular processes.Like other small GTPases,their core function is to act as molecular switches cycling between an“on”and“off”mode through exchange of bound GDP for GTP and subsequent hydrolysis of bound GTP to

INTRODUCTION Rab proteins are cytosolic small molecule GTPases that are recruited to the cytosolic leaflet of intracellular membranes where they function in various cellular processes. Like other small GTPases, whose core function is to act as molecular switches cycling between an “on” and “off” mode of exchange of bound GDP for GTP and subsequent hydrolysis of bound GTP to