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磷缺乏引起实验动物骨骼及代谢方面的损害,生理学家早有阐述,但对人体的损害,是60年代后才引起人们的重视。 1960年Bloom报导一例长期口服氢氧化铝胶引致病理骨折和骨软化症。1964年Lotz进一步研究这类病人,证实服用这类药物能引起低磷血症,病人虚弱无力、头晕、厌食、骨疼,长期服用可发生骨软化症。以后报导的这类病例日渐增多。近年国外广泛使用血液化学自动分析仪器作常规筛选化验之
Phosphorus deficiency causes damage to the bones and metabolism of experimental animals. Physiologists have long elaborated on them, but their damage to human body was not paid much attention until the 1960s. Bloom in 1960 reported a long-term oral administration of aluminum hydroxide gel causes pathological fractures and osteomalacia. Lotz in 1964 to further study of such patients, confirmed that taking these drugs can cause hypophosphatemia, the patient weakness, dizziness, anorexia, bone pain, long-term use can occur osteomalacia. The number of such cases reported later is increasing. In recent years, extensive use of blood chemistry automated analytical instruments for routine screening tests