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据北京协和医院和上海光华医院的统计,约50%的类风湿关节炎患者最初治疗即用肾上腺皮质激素(下简称激素),或来诊时仍在应用,有的以年计,如强地松30～40mg/d,以后维持量10～15mg/d。国内这种现象显然是不合理的,多数情况下对病人是弊多利少。造成这种情况的原因是很多医生认为激素是一有免疫抑制作用的药,因而对很多自身免疫性疾病,包括类风湿关节炎理所当然可以使用。但是应当看到以下事实: 1.很多对激素的药理作用认识来自动物实验,例如小白鼠、大白鼠、兔注射激素后胸腺、脾、淋巴腺皆缩小,周围血中淋巴细胞溶化而减少,这显然是免疫
According to Beijing Union Medical College Hospital and Shanghai Guanghua Hospital, about 50% of patients with rheumatoid arthritis are initially treated with adrenal cortex hormone (hereinafter referred to as hormone), or when the consultation is still in use, and some in years, such as strong Loose 30 ~ 40mg / d, after the maintenance of the amount of 10 ~ 15mg / d. This phenomenon is obviously unreasonable in the country, in most cases the advantages of the less harm to the patient. The reason for this is that many physicians regard hormones as immunosuppressive drugs and can of course be used for many autoimmune diseases, including rheumatoid arthritis. But you should see the following facts: 1. A lot of understanding of the pharmacological effects of hormones from animal experiments, such as mice, rats, rabbits after injection of hormones thymus, spleen, lymph nodes are reduced, peripheral blood lymphocytes dissolved and reduced, which Obviously immune