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尼索地平(Nisoldipine)属于二氢吡啶类的血管扩张剂,是一种速效、长效、适应症宽、副作用小的新型钙通道阻滞荊,能增加冠脉血流量,降低心肌耗氧量,有预防心肌缺血及室性心律失常的作用。本文介绍用紫外分光光度法测定其含量。 1 仪器和药品紫外一可见分光光度计,型号分别为UV—210、730和751G。尼索地平样品,为药学系有机化学教研室提供;尼索地平精制品(自制),熔点149.5～150.5℃,用薄层层析法检查,未发现杂质斑点。
Nisoldipine is a dihydropyridine vasodilator, which is a new type of calcium channel blocker with quick response, long acting effect, wide indications and small side effects. It can increase coronary blood flow and reduce myocardial oxygen consumption , Prevent myocardial ischemia and ventricular arrhythmias role. This article describes the determination of its content by UV spectrophotometry. 1 instruments and medicines UV-visible spectrophotometer, models were UV-210, 730 and 751G. Nisoldipine samples for the Department of Pharmaceutical Sciences Department of Organic Chemistry; Nisoldipine refined products (homemade), melting point 149.5 ~ 150.5 ℃, by TLC, no impurity spots were found.