Synthesis of a New Rigid Bicyclic AMPP Ligand (TIAMPP) and Application in Asymmetric Hydrogenation

• 作 者: Da Chun GONG Ping WEI Hua ZHOU
• 机 构: Nanjing University of Technology
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: (S)-TIAMPP synthesis asymmetric hydrogenation

The new rigid bicyclic AMPP((S)-TIAMPP) has been synthesized from the corresponding Ticol and Ph2PCl. The application of (S)-TIAMPP in Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acids derivatives has been examined. Up to 93% ee was obtained.