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目的探讨老年单纯收缩期高血压(ISH)患者的血管活性物质与左心室肥厚(LVH)的相关性。方法收集未用过降压药物的老年高血压患者67例,分为ISH及双期高血压(SDH)两组,同期健康老年人40例作为对照组。分别应用超声多普勒技术、放射免疫技术测定三组血管活性物质参数。结果两个高血压组舒张功能受损指标与对照组有显著性差异(P<0.01),其中,ISH组更具显著性;心钠素(ANP),醛固酮(Aldo),血管紧张素(AngⅡ)水平两个高血压组明显升高而降钙素基因相关蛋白(CGRP)水平则较对照组下降(P<0.01)。结论ISH患者易出现舒张功能不全且同SDH患者一样存在血管活性物质的异常导致LVH。
Objective To investigate the correlation between vasoactive substances and left ventricular hypertrophy (LVH) in elderly patients with isolated systolic hypertension (ISH). Methods Sixty-seven elderly hypertensive patients without antihypertensive drugs were collected and divided into two groups: ISH and double-phase hypertension (SDH). Forty healthy elderly patients in the same period were taken as control group. Ultrasound Doppler technique and radioimmunoassay were used to measure the parameters of three groups of vasoactive substances. Results The indexes of diastolic dysfunction in the two hypertension groups were significantly different from those in the control group (P <0.01), of which the ISH group was more significant. The levels of ANP, Aldo, AngⅡ ) Levels were significantly higher in the two hypertension groups and the levels of CGRP were lower than those in the control group (P <0.01). Conclusions Patients with ISH are prone to diastolic dysfunction and the presence of vasoactive substances in patients with SDH leads to LVH.