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目的:对比血清学各指标在新生儿败血症诊断中的价值,探究该病临床诊断方法。方法:在我院2014年10月-2015年12月住院治疗的新生儿患儿中,随机抽取败血症患儿40例,记为A组;局部感染患儿40例,记为B组;无感染患儿40例,记为C组;3组患儿均接受实验室指标检测,包含超敏C反应蛋白(hs-CRP)、外周血白细胞(WBC)、降钙素原(PCT)。结果:3组新生儿血清学指标对比分析,A组患儿指标水平均高于B组与C组,且P均<0.05;B组患儿指标水平高于C组,P<0.05,统计学差异显著。败血症诊断金标准采用血培养阳性结果,A组患儿经hsCRP诊断,特异性、灵敏度为57.5%、85.0%;经PCT诊断,结果为45.0%、55.0%;2者联合诊断,特异性70.0%,灵敏度97.5%;联合诊断均较单独诊断效果显著,且P均<0.05,差异具有统计学意义。结论:hs-CRP与PCT联合诊断新生儿败血症效果显著,是值得临床推广运用的败血症诊断方法。
Objective: To compare the value of serological markers in the diagnosis of neonatal sepsis and to explore the clinical diagnosis of the disease. Methods: Forty children with neonatal sepsis admitted to our hospital from October 2014 to December 2015 were randomly selected and divided into group A (40 cases), group B (40 cases), and group B All 40 children were enrolled as group C. All three groups received laboratory tests, including hs-CRP, WBC and procalcitonin (PCT). Results: The comparative analysis of serological indexes of neonates in three groups showed that the indexes of children in group A were higher than those in group B and C (all P <0.05), and those in group B were higher than those in group C (P <0.05) Significant difference. The gold standard of sepsis diagnosis using blood culture positive results in children with A group of hsCRP diagnosis, specificity, sensitivity was 57.5%, 85.0%; by PCT diagnosis, the results were 45.0%, 55.0%; 2 combined diagnosis of a specificity of 70.0% , The sensitivity was 97.5%. The combined diagnosis was significantly better than the single diagnosis, and P <0.05, the difference was statistically significant. Conclusion: hs-CRP combined with PCT in the diagnosis of neonatal sepsis has a significant effect and is worthy of clinical application in the diagnosis of sepsis.