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关于某些T细胞在试管中如何溶解其它细胞的问题,最新观点认为是杀伤性作用,即溶解性T细胞可能释放出的微孔形成分子对靶细胞有直接致死作用。但有人对此提出了异议,认为是细胞溶解性T细胞诱导而引起靶细胞的自身死亡。这个观点得到了David S Ucker的有力支持。他指出,一种靶细胞内的突变成分控制着T细胞或糖肾上腺皮质激素的溶解能力。采用试管内T细胞的溶解作用模拟体内T细胞对病毒感染细胞或肿瘤细胞的处置方式,由此得出的精细作用机制或许具有很重大的实践意义。以微孔形成分子为基础(图a)的论点是源于T细胞溶解和补体系统可溶性因子溶解间的明显相似性。第一,化学分离实验导致在微孔形成的细胞溶解性T细胞和自然杀伤(NK)细胞中,发现细胞溶解分子(穿孔素或细胞溶素)与补体系统中具有溶解作用的微
The question of how some T cells dissolve other cells in a test tube has been considered as a lethal effect, ie the microporosity molecules that soluble T cells may release have a direct lethal effect on target cells. However, some people have raised objections, that is induced by cytolytic T cells caused by the death of the target cells. This view has been strongly supported by David S Ucker. He pointed out that a mutation in target cells controls the ability of T-cells or glucocorticoids to dissolve. Using in vitro T cell lysis to mimic the way T cells treat virally infected cells or tumor cells, the resulting fine mechanism of action may have significant practical implications. The argument based on micropore-forming molecules (panel a) is due to the apparent similarity between T cell lysis and lysis of the complement system soluble factor. First, chemo-separation experiments have led to the discovery that cytolytic molecules (perforin or cytolysin) and lysosomes that have a lytic effect in micropore-forming cytolytic T cells and natural killer (NK) cells