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目的 探讨小剂量胰岛素对急性血栓性脑梗死神经缺陷与认知障碍的治疗作用及其机制。方法 以小剂量胰岛素治疗血糖正常的急性血栓性脑梗死患者 ,一般用药组做对照 ,通过对患者治疗过程中血糖、血去甲肾上腺素 (NE)、多巴胺 (DA)、乙酰胆碱 (Ach)、P30 0 、神经缺陷评估、记忆评估的比较进行客观评价。结果 治疗组血糖变化不明显 ,DA、Ach无变化 ,NE变化有显著性。 P30 0 之 N2 、P3波潜伏期缩短、波幅增高 ,变化有显著性 ,神经缺陷康复积分显著提高 ,记忆评估改善不明显。结论 小剂量胰岛素对正常血糖的急性脑梗死患者运动、感觉、认知障碍有治疗作用 ,对记忆障碍改善无显著性。
Objective To investigate the therapeutic effect and mechanism of low-dose insulin on neurological defects and cognitive impairment in acute thrombotic cerebral infarction. Methods Acute thrombotic cerebral infarction patients with normal blood glucose were treated with low-dose insulin. The patients in general thrombotic cerebral infarction were treated with low-dose insulin. Blood glucose, blood NE, DA, Ach, P30 0, neurological defect assessment, memory evaluation of the objective evaluation. Results The treatment group, blood glucose did not change significantly, DA, Ach no change, NE changes were significant. P30 0 N2, P3 wave latency shortened, amplitude increased, the change was significant, neurologic deficit rehabilitation score was significantly improved, memory assessment did not improve significantly. Conclusion Low-dose insulin has a therapeutic effect on motor, sensory and cognitive impairment in patients with acute cerebral infarction with normal blood glucose, and no significant improvement in memory impairment.