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目的:探讨赖诺普利与贝那普利治疗高血压合并脑卒中的疗效及对血清非对称性二甲基精氨酸(ADMA)水平的影响,以期为高血压合并脑卒中的治疗提供指导。方法:选取2014年1月-2016年3月在我院确诊并接受治疗的高血压合并脑卒中246例,按随机数字表法将患者随机分为研究组、对照组和常规组,每组各82例。常规组采用基础治疗,研究组采用基础治疗联合赖诺普利治疗,对照组采用基础治疗联合贝那普利治疗。比较3组患者治疗前后血压参数、血清ADMA和Hcy水平、治疗效果和不良反应。结果:治疗前三组患者的血压参数(SBP、DBP和PP)、血清ADMA和Hcy水平、m RS评分均无显著差异;治疗后三组患者上述指标水平较治疗前均显著降低(P<0.05),且研究组患者指标水平明显低于对照组和常规组(P<0.05)。研究组治疗有效率明显高于对照组和常规组,对照组治疗有效率明显高于常规组,上述差异均具有统计学意义(P<0.05)。三组患者不良反应率无显著差异(P>0.05)。结论:赖诺普利和贝那普利均能有效降低高血压合并脑卒中患者血压水平,改善血管内皮功能,疗效显著;但赖诺普利的效果要比贝那普利更好,更值得临床推广。
Objective: To investigate the therapeutic effect of lisinopril and benazepril on hypertension complicated with stroke and its effect on the level of asymmetric dimethylarginine (ADMA), so as to provide guidance for the treatment of hypertension complicated by stroke. . Methods: A total of 246 hypertensive patients complicated with stroke diagnosed and treated in our hospital from January 2014 to March 2016 were randomly divided into study group, control group and conventional group according to random number table 82 cases. The patients in the conventional group received basic treatment. The study group received basic treatment combined with lisinopril and the control group received basic treatment combined with benazepril treatment. Blood pressure parameters, serum ADMA and Hcy levels, treatment effects and adverse reactions were compared between the three groups before and after treatment. Results: The blood pressure parameters (SBP, DBP and PP), serum ADMA and Hcy levels, and mRS scores were not significantly different among the three groups before treatment. The levels of these indexes in the three groups after treatment were significantly lower than those before treatment (P <0.05 ), And the research group patients index level was significantly lower than the control group and conventional group (P <0.05). The effective rate of treatment in study group was significantly higher than that in control group and routine group. The treatment effective rate in control group was significantly higher than that in routine group. The differences were statistically significant (P <0.05). There was no significant difference in adverse reactions between the three groups (P> 0.05). Conclusion: Both lisinopril and benazepril can effectively reduce the blood pressure and improve the endothelial function in hypertensive patients with stroke, but the effect of lisinopril is better than that of benazepril Promotion.