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目的:探讨中国HIV+/AIDS 患者神经心理功能特点及情绪状态。方法:选取年龄、性别和受教育年限方面均匹配的28例HIM+和23例HIV-被试。对被试进行包含七个认知领域(如词语流畅、抽象/执行功能、信息处理速度、工作记忆、学习、延迟回忆和运动功能)的神经心理成套测验,共18个分测验。同时选用贝克抑郁问卷(BDI)让患者进行情绪自评。结果:单个测验粗分比较,HIV+/AIDS 被试比HIV-被试在范畴流畅测验、词语发音流畅测验、连线测验A、颜色连线测验Ⅱ及霍普金斯词语学习测验显著较差(P<0.05)。基于美国常模校正的标准分(T 分)显示,HIV+/AIDS 被试比HIV-被试在整套测验、词语流畅、抽象/执行功能和学习领域神经心理操作显著较差(P<0.05)。中国HIV-被试的平均T 分与美国常模50相近,总的平均T 分为48,各认知领域的平均T 分范围46-51。BDI 自评分提示中国HIV+/AIDS 被试比HIV-被试显示出更严重的抑郁情绪(P<0.001),且与躯体状况无关。HIV+/AIDS 被试BDI 得分与总的平均T 分无显著相关(r=0.22,p=0.27)。结论: 1.本研究所选用的神经心理成套测验有较为理想的跨文化效能。2.中国HIV/AIDS 被试在词语流畅、抽象/执行功能、学习认知领域和总的神经心理功能上比HIV--试显著较差,抑郁情绪更为严重,但抑郁情绪与HIV 造成的各领域认知功能损害无显著相关,提示HIV 可能对大脑的认知功能有一定影响。
Objective: To investigate the neuropsychological function and emotional status of HIV / AIDS patients in China. METHODS: Twenty-eight HIM + and 23 HIV-matched subjects were selected in terms of age, gender and years of schooling. Subjects were tested in a neuropsychological suite of seven cognitive domains, including fluent speech, abstraction / executive function, information processing speed, working memory, learning, delayed recall, and motor function. At the same time use the Beck Depression Questionnaire (BDI) for emotional self-evaluation of patients. Results: Compared with HIV-1 subjects, HIV + / AIDS subjects were significantly worse than those of HIV-1 subjects in terms of fluency test, smooth pronunciation of words, connection test A, color connection test Ⅱ and Hopkins test of speech P <0.05). The standard scores (T points) based on US Normalized Modifications showed that HIV + / AIDS subjects had significantly poorer neuropsychological performance (P <0.05) than HIV-subjects in the entire set of tests, fluent words, abstraction / executive function, and learning. The average T-score of HIV-subjects in China is similar to that of the US Norm 50, with a total mean T score of 48 and an average T-score range of 46-51 for each cognitive field. The BDI self-rating suggests that Chinese HIV + / AIDS subjects showed more severe depression (P <0.001) than HIV-subjects, regardless of their physical status. There was no significant correlation between BDI score of HIV + / AIDS subjects and total mean T score (r = 0.22, p = 0.27). Conclusion: 1. The neuropsychological test used in this study has an ideal cross-cultural efficacy. HIV / AIDS subjects in China were significantly worse than HIV-test in terms of fluency, abstraction / executive function, cognitive learning and overall neuropsychological function, depression was more serious, but depression and HIV Cognitive impairment in all fields was not significantly correlated, suggesting that HIV may have some impact on the cognitive function of the brain.