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目的 :研究 p170表达、免疫分型在恶性血液病中的临床意义。方法 :40例恶性血液病患者用异硫氰荧光与间接免疫标记法、流式细胞仪及软件系统进行检测和分析。结果 :初治恶性血液病患者 p170阳性表达率45 .0 % ,初治急性白血病外周血 p170高表达占 30 .7%。结论 :p170、CD34以及白血病两系抗原共表达三者间有明显相关性。同时它们又分别是一独立的负性预后指标 ,有利于指导临床医师采用个体化治疗。
Objective: To study the clinical significance of p170 expression and immunophenotyping in hematologic malignancies. Methods: Forty patients with hematologic malignancies were detected by isothiocyanate fluorescence and indirect immunofluorescence, flow cytometry and software system. Results: The positive rate of p170 in patients with newly diagnosed hematologic malignancies was 45.0%. The high expression of p170 in peripheral blood of newly diagnosed acute leukemia patients was 30.7%. Conclusion: There is a significant correlation between the expression of p170, CD34 and leukemia two lines antigens. At the same time, they are respectively an independent negative prognostic indicator, which is conducive to guiding clinicians to adopt individualized treatment.