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癌转移病灶的细胞动力学和原发灶是相同的,还是转移病灶的细胞代谢快从转移机制及对抗癌剂的敏感性等关连来看,对其检索在临床上具有非常重要的意义。作者等对大肠癌原发灶和转移灶的细胞动力学进行了分析。对象和方法:3例大肠癌肝转移病例,分别就正常大肠粘膜、癌原发灶、淋巴结转移灶、肝转移灶进行细胞动力学分析。在癌病灶切除前5～7小时,给予溴去氧尿苷(BudR)1000mg,进行闪光标记。以流动血细胞计数获得二元变量BudR/DNA的分布,用移动相方法进行分析。
The relationship between the cellular dynamics of the cancer metastasis and the primary tumor is the same, or whether the metastasis of the metastatic lesion is rapidly related to the mechanism of metastasis and the sensitivity of the anticancer agent. It is of great significance to search for the metastasis. The authors analyzed the cellular dynamics of colorectal cancer primary and metastatic lesions. OBJECTIVES AND METHODS: Three cases of liver metastases from colorectal cancer were analyzed for cell dynamics in normal colorectal mucosa, primary tumors, lymph node metastases, and liver metastases. 5 to 7 hours before the resection of the cancerous lesion, 1000 mg of bromodeoxyuridine (BudR) was administered and flash-marked. The binary variable BudR/DNA distribution was obtained by flow cytometry and analyzed by the mobile phase method.