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目的:探讨甲泼尼龙联合高渗盐水雾化治疗毛细支气管炎的疗效。方法:将130例患儿随机分为对照组和治疗组各65例。对照组给予改善通气、氧疗、抗感染、化痰、止咳、镇静、吸入沙丁胺醇平喘、补液等常规综合治疗;治疗组在对照组基础上,给予静脉滴注甲泼尼龙1～2 mg/kg,2～3次/d,连用3 d,3 d后开始减量,并予高渗盐水(生理盐水2.5 mL+10%氯化钠1.5 mL)加压雾化吸入,3～6次/d,疗程3～5 d。结果:治疗后治疗组在喘憋和呼吸困难消失时间、咳嗽消失时间、哮鸣音和湿啰音消失时间方面均优于对照组(P<0.05),治疗组总有效率96.9%,对照组总有效率83.1%,两组比较差异有统计学意义(P<0.05),且未发现与用药相关的明显不良反应。结论:甲泼尼龙联合高渗盐水雾化治疗毛细支气管炎安全有效。
Objective: To investigate the therapeutic effect of methylprednisolone combined with hypertonic saline on bronchiolitis. Methods: 130 children were randomly divided into control group and treatment group of 65 cases. The control group was given conventional therapy such as ventilation, oxygen therapy, anti-infection, phlegm, cough, sedation, inhalation of albuterol and asthma and rehydration. The treatment group was given intravenous methylprednisolone 1 ~ 2 mg / kg, 2 ~ 3 times / d for 3 days, and then began to reduce after 3 days. The rats were treated with hypertonic saline (2.5 mL of saline and 1.5 mL of 10% sodium chloride) d, treatment 3 ~ 5 d. Results: After treatment, the treatment group was superior to the control group (P <0.05) in the disappearance of wheezing and dyspnea, cough disappearance time, wheeze and wet rales disappearance time, the total effective rate was 96.9% in the treatment group, The total effective rate was 83.1%. There was a significant difference between the two groups (P <0.05), and no obvious adverse drug reactions were found. Conclusion: Methylprednisolone combined with hypertonic saline spray is safe and effective for the treatment of bronchiolitis.