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致敏淋巴细胞受相应抗原作用后,可产生各种可溶性非抗体产物,其中之一,能抑制巨噬细胞的正常移动,称之为巨噬细胞移动抑制因子(MIF)。该因子无族特异性,可用豚鼠腹腔巨噬细胞作为指示细胞,以判断MIF产生与否,此即通常所用的巨噬细胞移动抑制(MMI)试验。如人体淋巴细胞经某种抗原作用后能产生MIF,即表示机体对该抗原有特异性细胞免疫反应。1967年Sφborg和Bendixen发现用人体本身的白细胞也可作为指示细胞,从而发展为白细胞移动抑制(LMI)试验。
Sensitized lymphocytes by the corresponding antigen, can produce a variety of soluble non-antibody products, one of which can inhibit the normal macrophage migration, called macrophage migration inhibitory factor (MIF). This factor is non-family specific. Guinea pig peritoneal macrophages can be used as indicator cells to determine if MIF is present or not, which is commonly used in macrophage migration inhibition (MMI) assays. Such as human lymphocytes by some kind of antigen can produce MIF, which means that the body has a specific cellular immune response to the antigen. Søborg and Bendixen discovered in 1967 that leukocytes from the human body themselves could also be used as indicator cells to develop leukocyte migration inhibition (LMI) tests.